Vaping during pregnancy causes long-term lung effects in mouse offspring

In the study, pregnant mice were exposed to e-cigarette vapor with nicotine, e-cigarette vapor without nicotine, or filtered air. The researchers examined the offspring at five months of age and found reduced lung function and signs of startling in mice exposed to e-cigarette vapor with or without nicotine. They also found that the female mice had a significantly higher body weight as adults, but not at birth. The research has been published in The American Journal of Physiology-Lung Cell and Molecular Physiology.

“The dangers of smoking traditional cigarettes during pregnancy are well documented, including sudden infant death syndrome, low birth weight, and asthma, but the effects of exposure to e-cigarette vapor during development are unclear. Vaping has only been around since the early 2000s and little research has been done during the in utero period. Our findings indicate that vaping during pregnancy may have long-term effects on the health of the offspring,” said Matthew Gorr, lead author of the study and assistant research professor at The Ohio State University College of Nursing.

Most e-cigarettes contain nicotine, an addictive drug that can damage a baby’s brain, lungs and other developing organs. They also contain chemicals, flavorings and other additives that can negatively impact health. In a 2015 study, about 7% of women said they vaped while pregnant, despite warnings from the Centers for Disease Control and Prevention.

“E-cigarettes have been touted as being safer than traditional cigarettes and while this is true there are still health consequences. Clinical research is only just beginning to pick up speed as it is clear that e-cigarettes are not going away. We need this kind of research to help guide policy in a largely unregulated market,” said Loren Wold, study co-author and associate dean for research operations and compliance. at the College of Medicine.

The e-cigarette market has continued to grow exponentially and is expected to exceed $60 billion worldwide by 2025, outpacing sales of traditional cigarettes. As of 2014, e-cigarettes have been the most widely used tobacco product among young Americans, according to the CDC.

Next, Ohio State researchers will examine whether people exposed to vaping in utero will develop more harmful lung diseases as they age, especially when they experience other lung problems such as asthma or infection.

The research is funded by the National Institutes of Health and is part of a $5.5 million grant from the American Heart Association awarded in 2020 to researchers from the faculties of medicine, nursing, public health, and college. engineering from Ohio State University. Other research focuses on the most effective regulations to reduce the appeal and addiction of electronic cigarettes for young people and the best methods to help young people kick their addiction to electronic cigarettes.

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