Study in OSU mice shows vaping has long-term effects on hearts in men, but not women

A new study from the OSU College of Medicine provides new insight into the cardiovascular effects of vaping in adolescents.

The researchers were surprised to find that vaping had a significant long-term impact on the hearts of men, but not women.

For the study, mice were exposed to nicotine-containing vapors from an age that would equate to 12 to 30 years of age in humans.

Researchers found a reduction in heart function in male mice over time, but surprisingly, female mice were unaffected.

The females also had much higher amounts of an enzyme, CYP2A5 (CYP2A6 in humans) that breaks down nicotine.

Loren Wold, associate dean for search operations and compliance at the OSU College of Medicine and lead author of the study, issues a warning about the findings.

“We’re not saying women are always protected and it’s okay for women to vape. What we’re saying is that at this point they’re protected, but we don’t know what the long-term consequences. ,” he said.

The next step in research is to determine when in adolescent development cardiac dysfunction occurs and to confirm whether the CYP2A6 enzyme helps protect women from developing vaping-induced heart problems.

The results were published Monday in Traffica journal of the American Heart Association.

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