Mouse study: vaping has long-lasting effects on the hearts of adolescent males, but not females
In the mouse study, researchers found that vaping had a significant, long-term cardiovascular effect on adolescent males, but not on females. The results were published today in Circulation, a journal of the American Heart Association.
The mice were exposed to an e-cigarette aerosol mixture of propylene glycol and vegetable glycerin and nicotine, starting at the human equivalent of about 12 years old and up to about 30 years old in humans. The researchers found a reduction in heart function in men over time, but heart function in women was unaffected. Women also had a significantly higher amount of CYP2A5 (CYP2A6 in men), an enzyme that breaks down nicotine, than men.
The next step in research is to determine when in adolescent development cardiac dysfunction occurs and to confirm whether the CYP2A6 enzyme helps protect women from developing vaping-induced heart problems.
Media Contact: Amy Colgan, Wexner Medical Center Media Relations, [email protected]