HFpEF Win from Dapagliflozin; Angiographies of seropositives; Side effects of PCSK9 inhibitors?
For heart failure patients with mildly reduced or preserved ejection fraction in the DELIVER trial, dapagliflozin (Farxiga) helped reduce the risk of cardiovascular death and worsening heart failure, announced AstraZeneca, paving the way for a new indication in the future.
But how many real-world heart failure patients would actually be eligible for SGLT2 inhibitors based on the trial criteria? (Heart Failure Diary)
A study linking hypertensive disorders of pregnancy to long-term cardiovascular disease suggested benefit in screening women with a history of preeclampsia or gestational hypertension for several established cardiovascular risk factors. (Journal of the American College of Cardiology)
An urgent call to screen for familial hypercholesterolemia in children. (European journal of the heart)
Among Asian American subgroups, women of Indian descent were most at risk of death from ischemic heart disease, and Indians of both sexes were most at risk of death from heart failure, while Vietnamese had highest risk of death from cerebrovascular disease. (Circulation: quality and cardiovascular results)
E-cigarette users who do not smoke cigarettes do not have excess short-term cardiovascular disease compared to non-smokers. (Traffic)
Out-of-hospital cardiac arrest survivors had a 10-year survival rate of around 63% across all continents, according to a meta-analysis. (JAMA Cardiology)
Coronary angiograms of HIV-positive individuals with acute coronary syndrome tended to show more diffuse significant coronary lesions, coronary artery aneurysms, coronary artery ectasia, and more TIMI 3 flow from the culprit lesion rather than flow TIMI 0. (Circulation: Cardiovascular Interventions)
In a remote region of Germany, acute ischemic stroke patients reached endovascular treatment faster when they were transferred by helicopter instead of being taken to a stroke hospital. (JAMA)
Meanwhile, in a non-urban part of Spain, direct transport to a stroke center capable of thrombectomy or a local stroke hospital resulted in similar functional outcomes for stroke patients with suspected stroke. large vessel occlusion. (JAMA)
CathVision said the FDA has granted 510(k) clearance to its ECGenius electrophysiology recording system.
A Japanese center’s protocol for explantation of a left ventricular assist device after myocardial salvage appeared safe and associated with good long-term outcomes in people with dilated cardiomyopathy. (ESC heart failure)
A meta-analysis showed that PCSK9 inhibitors were associated with severe injection site reactions, but not cataracts, gastrointestinal bleeding, neurocognitive events, new-onset diabetes, severe myalgia or muscle pain. (Heart)
A cardiologist in Canada is facing mounting accusations of sexual assault from former patients, Calgary police have said.