Examine the effects of vaping on reproductive health

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Reproductive biologist Dr Ali Honaramooz and his research team design an experiment for researchers to identify and study the effects of electronic cigarette use on the health and development of testicular tissue, in detail. Inspired by figures released by Health Canada in 2020, claiming that adolescent vaping tripled between 2014 and 2019, the study aims to examine the effects of vaping on adolescent reproductive health development.

“I generally look for important, day-to-day or clinical questions that can be answered using my specialty and the study tools we have at our disposal,” Honaramooz said. “As a father of three teenagers, I think this research can help shed light on some aspects of electronic cigarettes that are not sufficiently studied and can help educate young people and their parents, as well as practitioners and policy makers. . “

Study author says calling e-cigs “less harmful” is misleading

The researcher said pregnant women tended to defend their use of these products as a healthy alternative to conventional cigarettes in their survey responses. However, he added, “the use of the word ‘healthier’ in this context, as if it were synonymous with ‘less harmful’, is misleading, even misleading. In the absence of evidence, the premise for claiming that electronic cigarettes are less harmful than smoking is precarious. “

Meanwhile, contradicting Honaramooz’s claims, there are in fact countless peer-reviewed studies indicating that e-cigarettes are significantly less harmful than combustible tobacco products. In fact, a recent report from Public Health England (PHE) not only reaffirmed that vaping is relatively safer, but also that it is a gateway to quitting smoking.

However, Honaramooz says that unlike other systems in the vital body which are fully developed at birth, the reproductive system remains purposely underdeveloped until puberty, so it is susceptible to being disturbed by carcinogens. In order to determine the possible negative effects of vaping, the biologist and his team regenerated functional testicular tissue from stem cells by modifying the technique of implantation of testicular cell aggregates.

Exposure of testicular cells to potential carcinogens

Eventually, they plan to introduce a number of potential carcinogens, a plan that includes exposing cells to e-cig vapor in order to study its effects on living tissue directly and in real time. “You see, toxicology is all about dose. … At reasonably relevant doses, I would probably expect to see subtle changes such as gene expression and possibly cell behavior, ”Honaramooz said. “Again, the effects don’t have to be significant or visible to have major functional consequences. … [Even subtle differences] can lead to carcinoma and cancer of the testes of the germ cells.

In the meantime, Honaramooz is warning consumers to beware of products marketed as healthy, especially where common sense suggests otherwise. “My own advice is to stick with what has worked over millions of years of evolution: basic, unmodified, primary foods and beverages in their natural, unmodified form, just as we follow. manufacturer’s instructions for choosing fuel for our cars. “

Read more : MedicalXpress

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