Alcohol consumption and telomere length: Mendelian randomization clarifies the effects of alcohol

  • Vaiserman A, Krasnienkov D. Telomere length as a marker of biological age: state of the art, open questions and future perspectives. Before Genet. 2021;11:1816.

    Google Scholar article

  • Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, et al. Association between telomere length and the risk of cancer and non-neoplastic diseases: a Mendelian randomization study. JAMA Oncol. 2017;3:636–51.

    Google Scholar article

  • Madrid AS, Rasmussen KL, Rode L, Frikke-Schmidt R, Nordestgaard BG, Bojesen SE. Observational and genetic studies of short telomeres and Alzheimer’s disease in 67,000 and 152,000 individuals: a Mendelian randomization study. Eur J Epidemiol. 2020;35:147–56.

    Google Scholar article

  • Barrett EL, Richardson DS. Sex differences in telomeres and lifespan. Aging cell. 2011;10:913–21.

    CAS Google Scholar Article

  • Diez Roux AV, Ranjit N, Jenny NS, Shea S, Cushman M, Fitzpatrick A, et al. Race/ethnicity and telomere length in the multiethnic study of atherosclerosis. Aging cell. 2009;8:251–7.

    CAS Google Scholar Article

  • Lin X, Zhou J, Dong B. Effect of different levels of exercise on telomere length: a systematic review and meta-analysis. J Rehabilitation Med. 2019;51:473–8.

    Google Scholar article

  • Astuti Y, Wardhana A, Watkins J, Wulaningsih W. Smoking and telomere length: systematic review of 84 studies and meta-analysis. Approx Res. 2017;158:480–9.

    CAS Google Scholar Article

  • Strandberg TE, Strandberg AY, Saijonmaa O, Tilvis RS, Pitkälä KH, Fyhrquist F. Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Study of Businessmen. Eur J Epidemiol. 2012;27:815–22.

    Google Scholar article

  • Weischer M, Bojesen SE, Nordestgaard BG. Telomere shortening unrelated to smoking, body weight, physical activity and alcohol consumption: 4,576 individuals from the general population with repeated measurements 10 years apart. PLoS Genet. 2014;10:e1004191.

    Google Scholar article

  • Dixit S, Whooley MA, Vittinghoff E, Roberts JD, Heckbert SR, Fitzpatrick AL, et al. Alcohol consumption and leukocyte telomere length. Sci Rep. 2019;9:1–10.

    Google Scholar article

  • De Carvalho LM, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, et al. Effect of alcohol use disorder on cellular aging. Psychopharmacology. 2019;236:3245–55.

    Google Scholar article

  • Wang H, Kim H, Baik I. Associations of alcohol consumption and alcohol flushing response with leukocyte telomere length in Korean adults. Nutr Res Pract. 2017;11:334–9.

    CAS Google Scholar Article

  • Gelernter J, Polimanti R. Genetics of substance use disorders in the age of big data. Nat Rev Genet. 2021;22:712–29.

    CAS Google Scholar Article

  • Davey Smith G, Ebrahim S. “Mendelian randomization”: can genetic epidemiology contribute to understanding the environmental determinants of disease? Int J Epidemiol. 2003;32:1–22.

    Google Scholar article

  • O’keefe EL, Dinicolantonio JJ, O’keefe JH, Lavie CJ. Alcohol and cardiovascular health: J curves of Jekyll and Hyde. Prog Cardiovascular Dis. 2018;61:68–75.

    Google Scholar article

  • Allen NE, Sudlow C, Peakman T, Collins R. UK Biobank Data: Come Get It. Sci Transl Med. 2014;6:22.

    Google Scholar article

  • Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with extensive phenotyping and genomic data. Nature. 2018;562:203–9.

    CAS Google Scholar Article

  • Topiwala A, Ebmeier KP, Maullin-Sapey T, Nichols TE. Alcohol consumption and MRI markers of brain structure and function: a cohort study of 25.78 participants at the UK Biobank. Neuroimage Clin. 2022;35.

  • Codd V, Denniff M, Swinfield C, Warner S, Papakonstantinou M, Sheth S, et al. Initial measurement and characterization of leukocyte telomere length in 474,074 participants at UK Biobank. Nat. aging 2022;2:170–9.

    Google Scholar article

  • Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, et al. Association studies involving up to 1.2 million individuals provide new insights into the genetic etiology of tobacco and alcohol use. Nat Genet. 2019;51:237–44.

    CAS Google Scholar Article

  • Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, et al. A multivariate Mendelian randomization analysis of smoking and alcohol consumption in cancer of the mouth and oropharynx. Common Nat. 2020;11:1–10.

    Google Scholar article

  • Burgess S, Davies NM, Thompson SG. Participant overlap bias in Mendelian two-sample randomization. Genet Epidemiol. 2016;40:597–608.

    Google Scholar article

  • Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, et al. A genome-wide meta-analysis of problematic alcohol use in 435,563 people provides insight into the biology and relationships to other traits. Nat Neurosci. 2020;23:809–18.

    CAS Google Scholar Article

  • Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, et al. Polygenic basis and biomedical consequences of telomere length variation. Nat Genet. 2021;53:1425–33.

    CAS Google Scholar Article

  • Verbanck M, Chen CY, Neale B, Do R. Detection of generalized horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693–8.

    CAS Google Scholar Article

  • Hemani G, Tilling K, Davey, Smith G. Directing the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13:e1007081.

    Google Scholar article

  • Doherty A, Smith-Byrne K, Ferreira T, Holmes MV, Holmes C, Pulit SL, et al. GWAS identifies 14 loci for physical activity and sleep duration measured by the device. Common Nat. 2018;9:1–8.

    CAS Google Scholar Article

  • Carvalho AF, Heilig M, Perez A, Probst C, Rehm J. Alcohol use disorders. Lancet. 2019;394:781–92.

    Google Scholar article

  • Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, et al. Genome-wide association study of alcohol use and use disorders in 274,424 people from multiple populations. Common Nat. 2019;10:1–11.

    Google Scholar article

  • Rosenström T, Torvik FA, Ystrom E, Czajkowski NO, Gillespie NA, Aggen SH, et al. Prediction of alcohol use disorder using personality disorder traits: a twin study. Addiction. 2018;113:15–24.

    Google Scholar article

  • Li JJ, Savage JE, Kendler KS, Hickman M, Mahedy L, Macleod J, et al. Polygenic risk, personality dimensions and alcohol use problems in adolescents: a longitudinal study. J Stud Alcohol Drugs. 2017;78:442–51.

    Google Scholar article

  • Polimanti R, Peterson RE, Ong JS, Macgregor S, Edwards AC, Clarke TK, et al. Evidence for the Causal Effect of Major Depression on Alcohol Dependence: Results from the Psychiatric Genomics Consortium. Psychol Med. 2019;49:1218–26.

    Google Scholar article

  • Kamper-Jørgensen M, Grønbæk M, Tolstrup J, Becker U. Alcohol and cirrhosis: dose-response or threshold effect? J Hepatol. 2004;41:25–30.

    Google Scholar article

  • Reichert S, Stier A. Does oxidative stress shorten telomeres in vivo? A review. Biol Lett. 2017;13:20170463.

    Google Scholar article

  • Das SK, Vasudevan D. Alcohol-induced oxidative stress. Life Sci. 2007;81:177–87.

    CAS Google Scholar Article

  • OR Koch, G Pani, S Borrello, R Colavitti, A Cravero, S Farrè, et al. Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol Asp Med. 2004;25:191–8.

    CAS Google Scholar Article

  • Colell A, García-Ruiz C, Miranda M, Ardite E, Marí M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998;115:1541–51.

    CAS Google Scholar Article

  • Tune in BF. Prevalence and correlates of DSM-IV alcohol consumption and alcohol dependence in the United States: results from the National Longitudinal Alcohol Epidemiological Survey. J Stud Alcohol. 1997;58:464–73.

    CAS Google Scholar Article

  • Dlouha D, Maluskova J, Lesna IK, Lanska V, Hubacek J. Comparison of relative telomere length measured in leukocytes and eleven different human tissues. Physiological Res. 2014;63:S343.

    CAS Google Scholar Article

  • Comments are closed.