Adverse effects of e-cigarettes on the head, neck, and oral cells: a systematic review
This article was originally published here
J Oral Pathol Med. 2022 Jan 19. doi:10.1111/jop.13273. Online ahead of print.
ABSTRACT
BACKGROUND: Electronic cigarette sales in the United States (US) are expected to reach 16.5 billion by 20241 . Six deaths and 450 lung diseases have been linked to e-cigarette use1 . To our knowledge, there is no systematic review of the adverse effects of e-cigarettes on the head, neck, and oral cells. This review aimed to perform a systematic review of the current literature to determine whether e-cigarettes cause adverse effects on cells in the head, neck and oral cavity.
METHODS: Five databases, including Medline, Dentistry and Oral Sciences, CINAHL, CAPLUS, Web of Science, and gray literature, were searched for articles at any time through December 2020. of the Rayyan software, two independent researchers reviewed 233 articles and extracted 41 for further investigation. . Based on the inclusion criteria, 18 articles were eligible for this review.
RESULTS: Aberrant morphology, cytotoxicity, oxidative stress, reduced viability, delayed fibroblast migration, and genotoxicity were statistically significant when head, neck, and oral cells were exposed to e-cigarettes. Of note, most articles in this systematic review found that cigarette smoke was significantly more toxic to head, neck, and mouth cells than e-cigarettes.
CONCLUSIONS: E-cigarettes are implicated in adverse effects on head, neck, and oral cells, but very few have been tested against these cells. More longitudinal studies using a wider variety of e-cigarettes are needed before their total adverse effects can be determined. Future research should also investigate chronic e-cigarette use and whether it leads to periodontal disease and/or head, neck or mouth cancer.
PMID:35048431 | DOI:10.1111/jop.13273
Comments are closed.